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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2826
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hprt1
Name: hypoxanthine phosphoribosyltransferase 1
Acc ID: CHEBI:82284
Term: 2-Amino-9H-pyrido[2,3-b]indole
Definition: A pyridoindole that has formula C11H9N3.
Chemical ID: MESH:C017822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hprt1multiple interactionsISOHPRT1 (Homo sapiens)6480464CTD[CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2,3-b)indole binds to and results in increased mutagenesis of HPRT1 gene]PMID:19243127
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