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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734157
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c29
Name: cytochrome P450, family 2, subfamily c, polypeptide 29
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c29affects metabolic processingISOCYP2C8 (Homo sapiens)6480464CTDCYP2C8 protein affects the metabolism of pioglitazonePMID:15900286
Cyp2c29decreases activityISOCYP2C8 (Homo sapiens)6480464CTDpioglitazone results in decreased activity of CYP2C8 proteinPMID:12642470
Cyp2c29increases expressionISOCYP2C8 (Homo sapiens)6480464CTDPioglitazone results in increased expression of CYP2C8 mRNAPMID:31233785
Cyp2c29multiple interactionsISOCYP2C8 (Homo sapiens)6480464CTDGemfibrozil inhibits the reaction [CYP2C8 protein affects the metabolism of pioglitazone]PMID:15900286
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