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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730988
Species: Homo sapiens
RGD Object: Gene
Symbol: VCAM1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VCAM1multiple interactionsISOVcam1 (Mus musculus)6480464CTDpioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]PMID:17015710
VCAM1multiple interactionsISOVcam1 (Rattus norvegicus)6480464CTDPioglitazone inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VCAM1 protein]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]PMID:16979161 PMID:30343038
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