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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ace2
Name: angiotensin converting enzyme 2
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ace2increases expressionEXP 6480464CTDPioglitazone results in increased expression of ACE2 proteinPMID:24114819 PMID:24558317
Ace2increases secretionEXP 6480464CTDPioglitazone results in increased secretion of ACE2 proteinPMID:24114819
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