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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:685566480464CTDPioglitazone results in decreased expression of CCND1 mRNA

PMID:26643070, PMID:30031879
decreases expressionISORGD:685576480464CTDpioglitazone results in decreased expression of CCND1 mRNA, pioglitazone results in decreased expression of CCND1 protein

PMID:17077279
multiple interactionsISORGD:685566480464CTDpioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of CCND1 protein]

PMID:26643070
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.