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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:82163
Term: rac-1,2-dichloropropane
Definition: A racemate comprising equimolar amounts of (R)- and (S)-1,2-dichloropropane. It is used as a fumigant to control nematodes in soil and insects in stored grain.
Chemical ID: MESH:C004765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases phosphorylationISORGD:13464646480464CTDpropylene dichloride results in increased phosphorylation of H2AX protein

PMID:28300663
H2axincreases phosphorylationISORGD:15581556480464CTDpropylene dichloride results in increased phosphorylation of H2AX protein

PMID:28300663
H2axmultiple interactionsISORGD:13464646480464CTD1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] Acetylcysteine inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] Disulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]

PMID:28300663
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