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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731289
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRB1
Name: adrenoceptor beta 1
Acc ID: CHEBI:8214
Term: pindolol
Definition: A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Chemical ID: MESH:D010869
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDPindolol results in increased activity of ADRB1 protein

PMID:12761341
increases expressionEXP 6480464CTDPindolol results in increased expression of ADRB1 protein

PMID:2175014
multiple interactionsEXP 6480464CTD[Pindolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP, CGP 20712A affects the reaction [Pindolol results in increased activity of ADRB1 protein], Pindolol binds to and results in decreased activity of ADRB1 protein, Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Pindolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]

PMID:12761341, PMID:14730417, PMID:15060759
affects bindingISORGD:20596480464CTDPindolol binds to ADRB1 protein

PMID:2462161
multiple interactionsISORGD:20596480464CTDPindolol binds to and results in decreased activity of ADRB1 protein, Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein], Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]

PMID:2462161, PMID:2888869
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.