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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10109
Species: Mus musculus
RGD Object: Gene
Symbol: Adrb2
Name: adrenergic receptor, beta 2
Acc ID: CHEBI:8214
Term: pindolol
Definition: A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Chemical ID: MESH:D010869
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb2affects bindingISOAdrb2 (Rattus norvegicus)6480464CTDPindolol binds to ADRB2 proteinPMID:2462161
Adrb2decreases expressionISOADRB2 (Homo sapiens)6480464CTDPindolol results in decreased expression of ADRB2 proteinPMID:2175014
Adrb2multiple interactionsISOAdrb2 (Rattus norvegicus)6480464CTDPindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]PMID:2462161
Adrb2multiple interactionsISOADRB2 (Homo sapiens)6480464CTD[Pindolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Pindolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Pindolol binds to and results in decreased activity of ADRB2 protein; Pindolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]PMID:14730417 PMID:17925438
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