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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:82036
Term: prothioconazole
Definition: A racemate comprising equal amounts of (R)- and (S)-prothioconazole. A fungicide for use both as a seed treatment and foliar spray to treat a variety of diseases in cereals.
Chemical ID: MESH:C550005
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahrdecreases activityISORGD:7310716480464CTDprothioconazole results in decreased activity of AHR protein

PMID:25684042
Ahrmultiple interactionsISORGD:7310716480464CTD[prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein, prothioconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

PMID:25684042
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.