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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10649
Species: Mus musculus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:81821
Term: ioxynil
Definition: A nitrile that is benzonitrile substituted by a hydroxy group at position 4 and iodo groups at positions 3 and 5.
Chemical ID: MESH:C008161
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1affects localizationISOGja1 (Rattus norvegicus)6480464CTDioxynil affects the localization of GJA1 protein; ioxynil analog affects the localization of GJA1 proteinPMID:20510257
Gja1decreases activityISOGja1 (Rattus norvegicus)6480464CTDioxynil analog results in decreased activity of GJA1 protein; ioxynil results in decreased activity of GJA1 proteinPMID:20510257
Gja1multiple interactionsISOGja1 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [ioxynil analog results in decreased activity of GJA1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ioxynil analog affects the phosphorylation of GJA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil analog results in decreased expression of GJA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil results in decreased expression of GJA1 protein]; ioxynil analog results in decreased expression of and affects the phosphorylation of GJA1 protein; ioxynil results in decreased expression of and affects the phosphorylation of GJA1 proteinPMID:20510257
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