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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69106
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:81763
Term: fludioxonil
Definition: A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria.
Chemical ID: MESH:C108339
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2multiple interactionsEXP 6480464CTDfludioxonil binds to and results in increased activity of NR1I2 proteinPMID:33049310
Nr1i2decreases expressionISONR1I2 (Homo sapiens)6480464CTDfludioxonil results in decreased expression of NR1I2 mRNAPMID:33575850
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I2 mRNA; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein; fludioxonil binds to and results in increased activity of NR1I2 proteinPMID:25028461 PMID:33049310 PMID:33575850
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