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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGaffects bindingEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether binds to PPARG protein; 2,2',4,4'-tetrabromodiphenyl ether metabolite binds to PPARG proteinPMID:25314719
PPARGincreases activityEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether analog results in increased activity of PPARG protein; 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased activity of PPARG protein; 2,2',4,4'-tetrabromodiphenyl ether results in increased activity of PPARG proteinPMID:26172262 PMID:28282128
PPARGincreases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PPARG mRNAPMID:23146750
PPARGmultiple interactionsEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether binds to and results in increased activity of PPARG proteinPMID:23398518
PPARGdecreases methylationISOPparg (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased methylation of PPARG promoterPMID:24559133
PPARGincreases expressionISOPparg (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PPARG mRNAPMID:24559133 PMID:29112739 PMID:29523931
PPARGmultiple interactionsISOPparg (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether promotes the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Dietary Fats promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PPARG mRNA]; ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PPARG mRNA]PMID:29112739 PMID:29523931
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