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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6affects expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether affects the expression of CYP2B6 mRNAPMID:31173147
CYP2B6increases chemical synthesisEXP 6480464CTDCYP2B6 protein results in increased chemical synthesis of 2,2',4,4'-tetrabromodiphenyl ether analogPMID:23249762
CYP2B6increases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP2B6 mRNAPMID:24218150
CYP2B6increases metabolic processingEXP 6480464CTDCYP2B6 protein results in increased metabolism of 2,2',4,4'-tetrabromodiphenyl etherPMID:23249762 PMID:23537005
CYP2B6multiple interactionsEXP 6480464CTD[2,2',4,4'-tetrabromodiphenyl ether results in increased activity of CYP3A4 protein] which results in increased expression of CYP2B6 mRNA; [2,2',4,4'-tetrabromodiphenyl ether results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNAPMID:24218150
CYP2B6increases expressionISOCyp2b10 (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP2B10 mRNAPMID:17324954 PMID:17964624 PMID:24218150 PMID:29112739 PMID:29523931
CYP2B6multiple interactionsISOCyp2b10 (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Dietary Fats results in increased expression of CYP2B10 mRNA]; Dietary Fats inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP2B10 mRNA]; ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CYP2B10 mRNA]; NR1I2 protein promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP2B10 mRNA]PMID:17324954 PMID:24218150 PMID:29112739 PMID:29523931
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