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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GCLC mRNAPMID:25659769
Gclcmultiple interactionsISOGCLC (Homo sapiens)6480464CTD[Eicosapentaenoic Acid analog co-treated with Docosahexaenoic Acids analog] promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GCLC mRNA]PMID:25659769
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