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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10187
Species: Mus musculus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether affects the expression of AR mRNAPMID:30294300
Armultiple interactionsISOAr (Rattus norvegicus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Metribolone binds to AR protein]PMID:16005038
Armultiple interactionsISOAR (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether analog binds to and results in decreased activity of AR protein; 2,2',4,4'-tetrabromodiphenyl ether binds to and results in decreased activity of AR protein; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]PMID:16005038 PMID:16601080 PMID:19672399 PMID:23398518
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