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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10765
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:81582
Term: 2,4-dibromophenyl 2,4,5-tribromophenyl ether
Definition: A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 4, 5, 2', and 4' positions have been replaced by bromines.
Chemical ID: MESH:C477694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1decreases expressionISOIGF1 (Homo sapiens)6480464CTD2,2',4,4',5-brominated diphenyl ether results in decreased expression of IGF1 mRNAPMID:26705709
Igf1increases expressionISOIgf1 (Rattus norvegicus)6480464CTD2,2',4,4',5-brominated diphenyl ether results in increased expression of IGF1 mRNAPMID:16414171
Igf1multiple interactionsISOIgf1 (Rattus norvegicus)6480464CTD2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]PMID:16414171
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