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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551432
Species: Mus musculus
RGD Object: Gene
Symbol: Oprm1
Name: opioid receptor, mu 1
Acc ID: CHEBI:81527
Term: beta-Funaltrexamine
Definition: A morphinane alkaloid that has formula C25H30N2O6.
Chemical ID: MESH:C024524
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oprm1multiple interactionsEXP 6480464CTD[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to NicotinePMID:15778877
Oprm1multiple interactionsISOOprm1 (Rattus norvegicus)6480464CTD[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to MorphinePMID:8884884
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