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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:81526
Term: endrin
Definition: An organochlorine compound resulting from the epoxidation of the double bond of isodrin. It is the endo, endo stereoisomer of dieldrin. It is an insecticide mainly used on field crops such as cotton and grains and has also been used as a rodenticide to control mice and voles. The product is banned in many countries since it is a persistent organic pollutant.
Chemical ID: MESH:D004732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISORGD:691056480464CTDEndrin results in increased activity of NR1I2 protein

PMID:15548381
Nr1i2multiple interactionsISORGD:691056480464CTDEndrin binds to and results in increased activity of NR1I2 protein

PMID:16054614
Nr1i2multiple interactionsISORGD:691066480464CTDEndrin binds to and results in increased activity of NR1I2 protein

PMID:21115097
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