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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:81522
Term: 2,3,3',4,4',5-Hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C087667
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases activityEXP 6480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl results in increased activity of CYP1A1 protein

PMID:16750337 PMID:18493746
Cyp1a1increases expressionEXP 6480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl results in increased expression of CYP1A1 mRNA 2 3 3' 4 4' 5-hexachlorobiphenyl results in increased expression of CYP1A1 protein

PMID:15352264 PMID:25654323 PMID:29738842
Cyp1a1multiple interactionsEXP 6480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] [Tetrachlorodibenzodioxin co-treated with 2 3 3' 4 4' 5-hexachlorobiphenyl] results in increased expression of CYP1A1 protein

PMID:11339718 PMID:16750337
Cyp1a1increases activityISORGD:104366480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl results in increased activity of CYP1A1 protein

PMID:10986007 PMID:16750337
Cyp1a1increases expressionISORGD:104366480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl results in increased expression of CYP1A1 mRNA

PMID:16750337 PMID:23674508
Cyp1a1multiple interactionsISORGD:104366480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

PMID:16750337
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