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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734055
Species: Mus musculus
RGD Object: Gene
Symbol: Ncf1
Name: neutrophil cytosolic factor 1
Acc ID: CHEBI:81520
Term: 2,3',4,4',5-Pentachlorobiphenyl
Definition: A pentachlorobiphenyl that has formula C12H5Cl5.
Chemical ID: MESH:C070055
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncf1increases expressionISONCF1 (Homo sapiens)6480464CTD2,3',4,4',5-pentachlorobiphenyl results in increased expression of NCF1 mRNAPMID:30821169 PMID:31251971
Ncf1increases localizationISONCF1 (Homo sapiens)6480464CTD2,3',4,4',5-pentachlorobiphenyl results in increased localization of NCF1 proteinPMID:20299304
Ncf1increases phosphorylationISONCF1 (Homo sapiens)6480464CTD2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of NCF1 proteinPMID:20299304
Ncf1multiple interactionsISONCF1 (Homo sapiens)6480464CTD2,3',4,4',5-pentachlorobiphenyl promotes the reaction [NCF1 protein binds to CYBB protein]; 2,3',4,4',5-pentachlorobiphenyl promotes the reaction [NCF1 protein modified form binds to CYBB protein]; acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; AHR protein affects the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of NCF1 mRNA]PMID:20299304 PMID:31251971
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