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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:81506
Term: 2,3,7,8-Tetrachlorodibenzofuran
Definition: A dibenzofuran that has formula C12H4Cl4O.
Chemical ID: MESH:C014211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD2, 3, 7, 8-tetrachlorodibenzofuran promotes the reaction [AHR protein binds to ARNT protein]

PMID:20951181
multiple interactionsISORGD:7327396480464CTD2, 3, 7, 8-tetrachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1A1 promoter], 2, 3, 7, 8-tetrachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1B1 promoter], 2, 3, 7, 8-tetrachlorodibenzofuran results in increased activity of [AHR protein binds to ARNT protein]

PMID:11294989, PMID:21703235
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.