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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730870
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A1
Name: cytochrome P450 family 1 subfamily A member 1
Acc ID: CHEBI:81501
Term: 1,2,3,7,8-Pentachlorodibenzodioxin
Definition: A dibenzodioxine that has formula C12H3Cl5O2.
Chemical ID: MESH:C051452
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A1increases expressionEXP 6480464CTD1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1A1 mRNA; 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1A1 proteinPMID:19447902 PMID:24472611 PMID:25654323 PMID:29738842
CYP1A1increases expressionISOCyp1a1 (Mus musculus)6480464CTD1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1A1 mRNAPMID:19041680 PMID:23674508 PMID:24472611
CYP1A1increases expressionISOCyp1a1 (Rattus norvegicus)6480464CTD1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1A1 mRNA; 1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of CYP1A1 proteinPMID:25654323 PMID:29738842
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