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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732146
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC5A1
Name: solute carrier family 5 member 1
Acc ID: CHEBI:8113
Term: phlorizin
Definition: An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2' via a glycosidic linkage.
Chemical ID: MESH:D010695
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC5A1affects bindingEXP 6480464CTDSLC5A1 protein binds to PhlorhizinPMID:17983207
SLC5A1multiple interactionsEXP 6480464CTDPhlorhizin inhibits the reaction [[Sodium co-treated with SLC5A1 protein] results in increased uptake of methylglucoside]; Phlorhizin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]PMID:16300400 PMID:17288452 PMID:17983207
SLC5A1decreases activityISOSlc5a1 (Mus musculus)6480464CTDPhlorhizin results in decreased activity of SLC5A1 proteinPMID:12927799
SLC5A1decreases activityISOSlc5a1 (Rattus norvegicus)6480464CTDPhlorhizin results in decreased activity of SLC5A1 proteinPMID:12663055
SLC5A1multiple interactionsISOSlc5a1 (Mus musculus)6480464CTD[Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of GlucosePMID:12927799
SLC5A1multiple interactionsISOSlc5a1 (Rattus norvegicus)6480464CTD[Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of spiraeosidePMID:12663055
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