GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2c65 | affects metabolic processing | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | CYP2C9 protein affects the metabolism of Phenytoin; CYP2C9 protein alternative form affects the metabolism of Phenytoin | PMID:15855726 PMID:20405111 PMID:27163851 | Cyp2c65 | decreases hydroxylation | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | CYP2C9 gene polymorphism results in decreased hydroxylation of Phenytoin | PMID:16873909 PMID:9860067 | Cyp2c65 | decreases metabolic processing | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | CYP2C9 5' UTR polymorphism results in decreased metabolism of Phenytoin; CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin | PMID:10208645 PMID:11434505 PMID:11503012 PMID:11740344 PMID:14659971 PMID:16220110 | Cyp2c65 | increases activity | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | Phenytoin results in increased activity of CYP2C9 protein | PMID:19202563 | Cyp2c65 | increases expression | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | Phenytoin results in increased expression of CYP2C9 mRNA | PMID:14600250 | Cyp2c65 | increases hydroxylation | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | CYP2C9 protein results in increased hydroxylation of Phenytoin | PMID:16873909 PMID:2025243 PMID:33961833 PMID:9110362 PMID:9860067 | Cyp2c65 | increases metabolic processing | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | CYP2C9 protein results in increased metabolism of Phenytoin | PMID:10208645 PMID:10510154 PMID:10850388 PMID:11234294 PMID:11668218 PMID:11740344 PMID:16220110 PMID:19082874 PMID:19715737 PMID:27163851 | Cyp2c65 | increases response to substance | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | CYP2C9 gene polymorphism results in increased susceptibility to Phenytoin | PMID:11740344 | Cyp2c65 | multiple interactions | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | [Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; [CYP2C9 protein results in increased hydroxylation of Phenytoin] which results in increased abundance of hydroxyphenytoin; Miconazole inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Phenytoin] which results in increased abundance of hydroxyphenytoin]; Miconazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Phenytoin]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA] | PMID:14600250 PMID:17961958 PMID:23397584 PMID:33961833 | | ||||||||||||||||||||||
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