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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737257
Species: Homo sapiens
RGD Object: Gene
Symbol: CA2
Name: carbonic anhydrase 2
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CA2decreases activityEXP 6480464CTDPhenylephrine results in decreased activity of CA2 proteinPMID:28800181
CA2increases expressionISOCar2 (Rattus norvegicus)6480464CTDPhenylephrine results in increased expression of CAR2 mRNA; Phenylephrine results in increased expression of CAR2 proteinPMID:17124262
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