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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731021
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC8A1
Name: solute carrier family 8 member A1
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC8A1decreases expressionISOSlc8a1 (Rattus norvegicus)6480464CTDPhenylephrine results in decreased expression of SLC8A1 proteinPMID:19244478
SLC8A1increases expressionISOSlc8a1 (Rattus norvegicus)6480464CTDPhenylephrine results in increased expression of SLC8A1 mRNAPMID:11179087
SLC8A1multiple interactionsISOSlc8a1 (Mus musculus)6480464CTDEGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]PMID:15621046
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