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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342656
Species: Homo sapiens
RGD Object: Gene
Symbol: KLF4
Name: KLF transcription factor 4
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KLF4decreases expressionISOKlf4 (Rattus norvegicus)6480464CTDPhenylephrine results in decreased expression of KLF4 mRNA; Phenylephrine results in decreased expression of KLF4 proteinPMID:19729022
KLF4multiple interactionsISOKlf4 (Rattus norvegicus)6480464CTDPhenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]PMID:19729022
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