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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:80830
Term: Germacrone
Definition: A germacrane sesquiterpenoid that has formula C15H22O.
Chemical ID: MESH:C048393
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3decreases activityISORGD:13467516480464CTDgermacrone results in decreased activity of CYP2B6 protein

PMID:23850985
Cyp2b3increases expressionISORGD:13467516480464CTDgermacrone results in increased expression of CYP2B6 mRNA

PMID:23850985
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.