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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736946
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB4
Name: ATP binding cassette subfamily B member 4
Acc ID: CHEBI:8081
Term: phentolamine
Definition: A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Chemical ID: MESH:D010646
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB4decreases activityEXP 6480464CTDPhentolamine results in decreased activity of ABCB4 proteinPMID:28437613
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