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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:80774
Term: tauroursodeoxycholic acid
Definition: A bile acid taurine conjugate derived from ursoodeoxycholic acid.
Chemical ID: MESH:C031655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDtauroursodeoxycholic acid inhibits the reaction [2, 4-dichlorophenol results in increased expression of DDIT3 mRNA], tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA], tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of DDIT3 mRNA], tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of DDIT3 protein], tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA]

PMID:27853103, PMID:28223344, PMID:29751043
multiple interactionsISORGD:623916480464CTDtauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of DDIT3 protein]

PMID:23544086
multiple interactionsISORGD:691656480464CTDtauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased expression of DDIT3 protein], tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]

PMID:24802810, PMID:25611565
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.