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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736631
Species: Homo sapiens
RGD Object: Gene
Symbol: ITGB1
Name: integrin subunit beta 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ITGB1increases expressionISOItgb1 (Rattus norvegicus)6480464CTDPhenobarbital results in increased expression of ITGB1 mRNAPMID:30047161
ITGB1multiple interactionsISOItgb1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ITGB1 mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of ITGB1 promoterPMID:25374375
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