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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRincreases expressionEXP 6480464CTDPhenobarbital results in increased expression of AHR mRNAPMID:28541575
AHRmultiple interactionsEXP 6480464CTD[NR1I2 protein co-treated with NR1I3 protein] affects the reaction [Phenobarbital results in increased expression of AHR mRNA]PMID:28058446
AHRdecreases activityISOAhr (Mus musculus)6480464CTDPhenobarbital results in decreased activity of AHR proteinPMID:30203046
AHRincreases expressionISOAhr (Mus musculus)6480464CTDPhenobarbital results in increased expression of AHR mRNA; Phenobarbital results in increased expression of AHR proteinPMID:17505019 PMID:19482888 PMID:21335049 PMID:23091169 PMID:28058446 PMID:28541575
AHRincreases expressionISOAhr (Rattus norvegicus)6480464CTDPhenobarbital results in increased expression of AHR mRNA; Phenobarbital results in increased expression of AHR proteinPMID:12011481 PMID:17505019 PMID:19162173 PMID:23273579 PMID:25182419
AHRmultiple interactionsISOAhr (Mus musculus)6480464CTDKetoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; NR1I3 protein affects the reaction [Phenobarbital results in increased expression of AHR mRNA]PMID:17505019 PMID:19482888
AHRmultiple interactionsISOAhr (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AHR protein; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]PMID:17505019 PMID:20935162 PMID:25489928
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