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RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of CASP12 mRNA

increases expressionISORGD:7314426480464CTDPhenobarbital results in increased expression of CASP12 mRNA

multiple interactionsISORGD:7314426480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CASP12 mRNA, NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CASP12 mRNA]

PMID:19482888, PMID:24535843
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.