GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621447
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnk1
Name: potassium two pore domain channel subfamily K member 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7317916480464CTDPhenobarbital affects the expression of KCNK1 mRNA

PMID:23091169
decreases response to substanceISORGD:7317916480464CTDKCNK1 results in decreased susceptibility to Phenobarbital

PMID:23291559
increases expressionISORGD:7317916480464CTDPhenobarbital results in increased expression of KCNK1 mRNA

Phenobarbital results in increased expression of KCNK1 protein

PMID:19270015, PMID:19482888, PMID:23291559
multiple interactionsISORGD:7317916480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KCNK1 mRNA

NR1I3 gene mutant form inhibits the reaction [Phenobarbital promotes the reaction [RXRA protein binds to KCNK1 promoter]]

NR1I3 gene mutant form inhibits the reaction [Phenobarbital results in increased expression of KCNK1 mRNA]

NR1I3 protein affects the reaction [Phenobarbital results in increased expression of KCNK1 mRNA]

Phenobarbital promotes the reaction [NR1I3 protein binds to KCNK1 promoter]

Phenobarbital promotes the reaction [RXRA protein binds to KCNK1 promoter]

PMID:19482888, PMID:23291559, PMID:24535843
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.