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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61926
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gjb1
Name: gap junction protein, beta 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gjb1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with Phenobarbital] results in decreased expression of GJB1 proteinPMID:1973356
Gjb1affects response to substanceISOGjb1 (Mus musculus)6480464CTDGJB1 affects the susceptibility to PhenobarbitalPMID:11016633
Gjb1increases response to substanceISOGjb1 (Mus musculus)6480464CTDGJB1 protein results in increased susceptibility to PhenobarbitalPMID:18308698
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