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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco2a1
Name: solute carrier organic anion transporter family, member 2a1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco2a1decreases expressionISOSlco2a1 (Mus musculus)6480464CTDPhenobarbital results in decreased expression of SLCO2A1 mRNAPMID:19482888
Slco2a1increases expressionISOSLCO2A1 (Homo sapiens)6480464CTDPhenobarbital results in increased expression of SLCO2A1 mRNAPMID:19084549
Slco2a1multiple interactionsISOSlco2a1 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of SLCO2A1 mRNA; NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SLCO2A1 mRNA]PMID:19482888 PMID:24535843
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