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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2984
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt8
Name: keratin 8
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of and results in increased phosphorylation of KRT8 protein, [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KRT8 mRNA, [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of KRT8 protein

PMID:19409407, PMID:20935162
affects expressionISORGD:7355366480464CTDPhenobarbital affects the expression of KRT8 mRNA

PMID:19159669
increases expressionISORGD:7355376480464CTDPhenobarbital results in increased expression of KRT8 mRNA

PMID:19482888
multiple interactionsISORGD:7355376480464CTDNR1I3 protein affects the reaction [Phenobarbital results in increased expression of KRT8 mRNA]

PMID:19482888
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.