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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2467
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b2
Name: cytochrome P450, family 2, subfamily b, polypeptide 2
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b2affects expressionEXP 6480464CTDPhenobarbital affects the expression of CYP2B2 mRNA; Phenobarbital affects the expression of CYP2B2 proteinPMID:18796496 PMID:23665940 PMID:24025784
Cyp2b2increases activityEXP 6480464CTDPhenobarbital results in increased activity of CYP2B2 proteinPMID:15093247 PMID:15490126 PMID:29366910 PMID:8246169
Cyp2b2increases expressionEXP 6480464CTDPhenobarbital results in increased expression of CYP2B2; Phenobarbital results in increased expression of CYP2B2 mRNA; Phenobarbital results in increased expression of CYP2B2 proteinPMID:10036216 PMID:10772642 PMID:10945841 PMID:11328961 PMID:11752103 PMID:12082028 PMID:12832660 PMID:12883083 PMID:15596064 PMID:15744758 PMID:16125621 PMID:16408618 PMID:16684660 PMID:16940010 PMID:1715015 PMID:18798224 PMID:19162173 PMID:19409404 PMID:19850644 PMID:20226384 PMID:20607812 PMID:21763762 PMID:22008536 PMID:22245121 PMID:23273579 PMID:24090815 PMID:29366910 PMID:29548889 PMID:31465819 PMID:7513451 PMID:8246169 PMID:8263600 PMID:8615872 PMID:9152597
Cyp2b2multiple interactionsEXP 6480464CTD[Orphenadrine co-treated with Phenobarbital] affects the expression of CYP2B2 mRNA; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA; Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA]; Chlordecone inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA]; Choline deficiency promotes the reaction [Phenobarbital results in increased expression of CYP2B2 protein]; NR1I3 gene mutant form inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA]; NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA]; Phenobarbital promotes the reaction [CYP2B2 protein results in increased oxidation of Toluene]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]; Piperonyl Butoxide affects the reaction [Phenobarbital affects the expression of CYP2B2 mRNA]PMID:11752103 PMID:18486174 PMID:18798224 PMID:1994898 PMID:21763762 PMID:23665940 PMID:24025784 PMID:29548889 PMID:7513451
Cyp2b2increases expressionISOCyp2b13 (Mus musculus)6480464CTDPhenobarbital results in increased expression of CYP2B13 mRNAPMID:19270015 PMID:19482888 PMID:20403969 PMID:21335049 PMID:23091169 PMID:31836555
Cyp2b2multiple interactionsISOCyp2b13 (Mus musculus)6480464CTDNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CYP2B13 mRNA]PMID:19482888
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