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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDPhenobarbital results in decreased expression of BAX mRNAPMID:23273579
Baxincreases expressionEXP 6480464CTDPhenobarbital results in increased expression of BAX proteinPMID:17456340
Baxdecreases expressionISOBax (Mus musculus)6480464CTDPhenobarbital results in decreased expression of BAX proteinPMID:10426811
Baxincreases expressionISOBax (Mus musculus)6480464CTDPhenobarbital results in increased expression of BAX mRNAPMID:19270015
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Lithocholic Acid co-treated with Phenobarbital] results in decreased expression of BAX protein; [Phenobarbital co-treated with MYC protein] results in increased expression of BAX protein; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of BAX mRNA]; Phenobarbital inhibits the reaction [MYC protein results in increased expression of BAX protein]PMID:10449034 PMID:19433268 PMID:9230198
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