Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Afp
Name: alpha-fetoprotein
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Afpmultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of AFP protein; myrrh resin analog inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]; piperlongumine inhibits the reaction [[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]PMID:28414157 PMID:35113675
Afpaffects expressionISOAfp (Mus musculus)6480464CTDPhenobarbital affects the expression of AFP mRNAPMID:23091169
Afpincreases expressionISOAfp (Mus musculus)6480464CTDPhenobarbital results in increased expression of AFP mRNAPMID:19482888
Afpmultiple interactionsISOAfp (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP mRNA; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA; [Phenobarbital co-treated with Pregnenolone Carbonitrile co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA; NR1I3 protein affects the reaction [Phenobarbital results in increased expression of AFP mRNA]PMID:19482888 PMID:24535843 PMID:33398415
Go Back to source page   Continue to Ontology report