Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1619652
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a6b
Name: UDP glucuronosyltransferase 1 family, polypeptide A6B
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a6bdecreases expressionEXP 6480464CTDPhenobarbital results in decreased expression of UGT1A6B proteinPMID:35881160
Ugt1a6bdecreases expressionISOUGT1A6 (Homo sapiens)6480464CTDPhenobarbital results in decreased expression of UGT1A6 proteinPMID:28541575
Ugt1a6bincreases expressionISOUGT1A6 (Homo sapiens)6480464CTDPhenobarbital results in increased expression of UGT1A6 proteinPMID:35881160
Ugt1a6bincreases expressionISOUgt1a6 (Rattus norvegicus)6480464CTDPhenobarbital results in increased expression of UGT1A6 mRNA; Phenobarbital results in increased expression of UGT1A6 proteinPMID:17381134 PMID:17967931 PMID:19118567 PMID:19768707 PMID:24090815
Ugt1a6bmultiple interactionsISOUgt1a6 (Rattus norvegicus)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A6 mRNA]]; Phenobarbital promotes the reaction [Benzo(a)pyrene results in increased expression of UGT1A6 mRNA]PMID:25489928
Go Back to source page   Continue to Ontology report