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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352960
Species: Homo sapiens
RGD Object: Gene
Symbol: CES1
Name: carboxylesterase 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CES1increases expressionEXP 6480464CTDPhenobarbital results in increased expression of CES1 proteinPMID:10640517 PMID:35881160
CES1affects expressionISOCes1d (Mus musculus)6480464CTDPhenobarbital affects the expression of CES1D mRNAPMID:23091169
CES1increases expressionISOCes1d (Mus musculus)6480464CTDPhenobarbital results in increased expression of CES1D mRNA; Phenobarbital results in increased expression of CES1D proteinPMID:22513142 PMID:25270620 PMID:28541575
CES1increases hydrolysisISOCes1d (Mus musculus)6480464CTDCES1D protein results in increased hydrolysis of PhenobarbitalPMID:22513142
CES1multiple interactionsISOCes1d (Mus musculus)6480464CTDPhenobarbital results in increased expression of and results in increased activity of CES1D proteinPMID:22513142
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