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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349768
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTM3
Name: glutathione S-transferase mu 3
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTM3affects expressionISOGstm5 (Rattus norvegicus)6480464CTDPhenobarbital affects the expression of GSTM3 mRNAPMID:23665940 PMID:24025784
GSTM3increases expressionISOGstm5 (Rattus norvegicus)6480464CTDPhenobarbital results in increased expression of GSTM3 mRNA; Phenobarbital results in increased expression of GSTM3 proteinPMID:24418717 PMID:9794803
GSTM3increases expressionISOGstm5 (Mus musculus)6480464CTDPhenobarbital results in increased expression of GSTM3 mRNA; Phenobarbital results in increased expression of GSTM3 proteinPMID:18723825 PMID:19270015 PMID:19482888 PMID:20118494 PMID:20403969 PMID:21335049 PMID:23091169 PMID:28541575 PMID:30629241 PMID:33549593
GSTM3multiple interactionsISOGstm5 (Rattus norvegicus)6480464CTD[indole-3-carbinol co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GSTM3 mRNA; Piperonyl Butoxide affects the reaction [Phenobarbital affects the expression of GSTM3 mRNA]PMID:23665940 PMID:24025784 PMID:24418717
GSTM3multiple interactionsISOGstm5 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA; [Phenobarbital co-treated with CTNNB1 protein mutant form] results in increased expression of GSTM3 mRNA; NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GSTM3 mRNA]PMID:19482888 PMID:20118494 PMID:24535843 PMID:33549593
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