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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306605
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp46a1affects expressionISORGD:13153156480464CTDPhenobarbital affects the expression of CYP46A1 mRNA

PMID:23091169
Cyp46a1decreases expressionISORGD:13153156480464CTDPhenobarbital results in decreased expression of CYP46A1 mRNA

PMID:19482888
Cyp46a1multiple interactionsISORGD:13153156480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of CYP46A1 mRNA, NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CYP46A1 mRNA]

PMID:19482888, PMID:24535843
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.