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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731641
Species: Homo sapiens
RGD Object: Gene
Symbol: NPR3
Name: natriuretic peptide receptor 3
Acc ID: CHEBI:8064
Term: phenformin
Definition: A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidosis.
Chemical ID: MESH:D010629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NPR3increases expressionISONpr3 (Rattus norvegicus)6480464CTDPhenformin results in increased expression of NPR3 mRNAPMID:31324951
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