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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737013
Species: Homo sapiens
RGD Object: Gene
Symbol: TLR4
Name: toll like receptor 4
Acc ID: CHEBI:80630
Term: irinotecan
Definition: A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
Chemical ID: MESH:D000077146
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TLR4affects response to substanceISOTlr4 (Mus musculus)6480464CTDTLR4 protein affects the susceptibility to IrinotecanPMID:35728726
TLR4increases expressionISOTlr4 (Mus musculus)6480464CTDIrinotecan results in increased expression of TLR4 proteinPMID:28454924
TLR4multiple interactionsISOTlr4 (Mus musculus)6480464CTDSilymarin inhibits the reaction [Irinotecan results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [Irinotecan affects the expression of IL1B mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of NR1I2 mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of NR1I3 mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of TNF mRNA]; TLR4 protein affects the reaction [Irinotecan results in decreased expression of UGT1A1 mRNA]; TLR4 protein affects the reaction [Irinotecan results in increased expression of IL6 mRNA]PMID:28454924 PMID:35728726
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