GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ESR1 | decreases expression | EXP | | 6480464 | CTD | 4-hydroxy-N-desmethyltamoxifen results in decreased expression of ESR1 mRNA; 4-hydroxy-N-desmethyltamoxifen results in decreased expression of ESR1 protein | PMID:19244106 | ESR1 | increases degradation | EXP | | 6480464 | CTD | 4-hydroxy-N-desmethyltamoxifen results in increased degradation of ESR1 protein | PMID:19244106 | ESR1 | multiple interactions | EXP | | 6480464 | CTD | 4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein] | PMID:19244106 | | ||||||||||||||||||||||
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