GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP2D6 | increases abundance | EXP | | 6480464 | CTD | CYP2D6 protein results in increased abundance of N-desmethyltamoxifen | PMID:29285606 | CYP2D6 | increases metabolic processing | EXP | | 6480464 | CTD | CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen | PMID:29285606 | CYP2D6 | multiple interactions | EXP | | 6480464 | CTD | [CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of N-desmethyltamoxifen; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen | PMID:14652237 PMID:29285606 | | ||||||||||||||||||||||
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