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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:8040
Term: phalloidin
Definition: A homodetic bicyclic heptapeptide having a sulfide bridge.
Chemical ID: MESH:D010590
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDPhalloidine results in increased expression of DDIT3 mRNA

PMID:25280775
multiple interactionsEXP 6480464CTD[KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of DDIT3 mRNA, [NFE2L2 gene mutant form results in increased susceptibility to Phalloidine] which results in increased expression of DDIT3 mRNA, KEAP1 gene mutant form inhibits the reaction [Phalloidine results in increased expression of DDIT3 mRNA], NFE2L2 gene mutant form promotes the reaction [Phalloidine results in increased expression of DDIT3 mRNA], Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of DDIT3 mRNA]

PMID:25280775
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.