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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10785
Species: Mus musculus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:8005
Term: peptidoglycan
Definition: A peptidoglycosaminoglycan formed by alternating residues of beta-(1->4)-linked N-acetylglucosamine and N-acetylmuramic acid {2-amino-3-O-[(S)-1-carboxyethyl]-2-deoxy-D-glucose} residues. Attached to the carboxy group of the muramic acid is a peptide chain of three to five amino acids.
Chemical ID: MESH:D010457
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10increases expressionEXP 6480464CTDPeptidoglycan results in increased expression of IL10 mRNAPMID:17238832
Il10multiple interactionsEXP 6480464CTDMYD88 gene mutant form inhibits the reaction [Peptidoglycan results in increased expression of IL10 protein]; Peptidoglycan results in increased expression of and results in increased secretion of IL10 proteinPMID:17238832
Il10increases expressionISOIL10 (Homo sapiens)6480464CTDPeptidoglycan results in increased expression of IL10 proteinPMID:11169223
Il10increases secretionISOIL10 (Homo sapiens)6480464CTDPeptidoglycan results in increased secretion of IL10 proteinPMID:16224278
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTDSirolimus inhibits the reaction [Peptidoglycan results in increased expression of IL10 protein]PMID:11169223
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